diff --git a/typo3/cli_dispatch.phpsh b/typo3/cli_dispatch.phpsh
index 7b8acac0ed63fb6910a6241070f01b6bc9317910..57817392a7ca60af006bf8d609f3cbae308d2025 100755
--- a/typo3/cli_dispatch.phpsh
+++ b/typo3/cli_dispatch.phpsh
@@ -1,4 +1,5 @@
 #!/usr/bin/env php
 <?php
-
+// This entry-point is deprecated since TYPO3 v8 and will be removed in TYPO3 v9
+// Use the binary located typo3/sysext/core/bin/typo3 instead.
 require 'sysext/backend/Resources/Private/Php/cli.php';
diff --git a/typo3/sysext/backend/Classes/Console/Application.php b/typo3/sysext/backend/Classes/Console/Application.php
index cc52d82836c80aee88aa172bfb63dbabdfd2435b..edc09321a42b5e2b24a9daa873209b1e0e3df951 100644
--- a/typo3/sysext/backend/Classes/Console/Application.php
+++ b/typo3/sysext/backend/Classes/Console/Application.php
@@ -18,6 +18,10 @@ use TYPO3\CMS\Core\Core\Bootstrap;
 
 /**
  * Entry point for the TYPO3 Command Line for Backend calls
+ *
+ * This class is @deprecated in favor of the Core-based CommandApplication, which has a different
+ * entry-point level, and has a different request handler out-of-the-box. This class will be removed
+ * in TYPO3 v9.
  */
 class Application implements ApplicationInterface
 {
diff --git a/typo3/sysext/backend/Classes/Console/CliRequestHandler.php b/typo3/sysext/backend/Classes/Console/CliRequestHandler.php
index 6218dcfb181e93c9c50e2981d34f0e1c94ba6ed1..a623bde425c673a431047585c619cfaf3ac22e11 100644
--- a/typo3/sysext/backend/Classes/Console/CliRequestHandler.php
+++ b/typo3/sysext/backend/Classes/Console/CliRequestHandler.php
@@ -27,6 +27,8 @@ use TYPO3\CMS\Core\Utility\GeneralUtility;
  * Resolves the "cliKey" which is registered inside $TYPO3_CONF_VARS[SC_OPTIONS][GLOBAL][cliKeys]
  * and includes the CLI-based script or exits if no valid "cliKey" is found.
  * Also logs into the system as a backend user which needs to be added to the database called _CLI_mymodule
+ *
+ * This class is deprecated in favor of the Core-based CommandRequestHandler, which uses Symfony Commands.
  */
 class CliRequestHandler implements RequestHandlerInterface
 {
@@ -54,6 +56,8 @@ class CliRequestHandler implements RequestHandlerInterface
      */
     public function handleRequest(InputInterface $input)
     {
+        GeneralUtility::deprecationLog('Using cli_dispatch.phpsh as entry point for CLI commands has been marked '
+        . 'as deprecated and will be removed in TYPO3 v9. Please use the new CLI entrypoint via /typo3/sysext/core/bin/typo3 instead.');
         $output = GeneralUtility::makeInstance(ConsoleOutput::class);
         $exitCode = 0;
 
diff --git a/typo3/sysext/backend/Resources/Private/Php/cli.php b/typo3/sysext/backend/Resources/Private/Php/cli.php
index b5412ec3ed92310a94461ae8511de302ca817026..925c6c66454edbac4ff49b8e8ab3fbf16950033e 100644
--- a/typo3/sysext/backend/Resources/Private/Php/cli.php
+++ b/typo3/sysext/backend/Resources/Private/Php/cli.php
@@ -18,6 +18,10 @@ if (version_compare(PHP_VERSION, '7.0.0', '<')) {
 }
 
 /**
+ * --------------------------------------------------------------------------------
+ * NOTE: This entry-point is deprecated since TYPO3 v8 and will be removed in
+ * TYPO3 v9. Use the binary located typo3/sysext/core/bin/typo3 instead.
+ * --------------------------------------------------------------------------------
  * Command Line Interface module dispatcher
  *
  * This script takes a "cliKey" as first argument and uses that to dispatch
diff --git a/typo3/sysext/core/Classes/Console/CommandRequestHandler.php b/typo3/sysext/core/Classes/Console/CommandRequestHandler.php
index d3eb7a4eb434b02a24fc9985f573dd22ba23a967..27070f90a23fe16d2fee5edf30ed6a12be41b518 100644
--- a/typo3/sysext/core/Classes/Console/CommandRequestHandler.php
+++ b/typo3/sysext/core/Classes/Console/CommandRequestHandler.php
@@ -74,8 +74,10 @@ class CommandRequestHandler implements RequestHandlerInterface
         $command = $this->getCommandToRun($input);
 
         if (!$command) {
+            // Using old "cliKeys" is marked as deprecated and will be removed in TYPO3 v9
             $cliKeys = array_keys($GLOBALS['TYPO3_CONF_VARS']['SC_OPTIONS']['GLOBAL']['cliKeys']);
 
+            $output->writeln('Using old "cliKeys" ($GLOBALS[TYPO3_CONF_VARS][SC_OPTIONS][GLOBAL][cliKeys]) is marked as deprecated and will be removed in TYPO3 v9:');
             $output->writeln('Old entrypoint keys available:');
             asort($cliKeys);
             foreach ($cliKeys as $key => $value) {
diff --git a/typo3/sysext/core/Configuration/DefaultConfiguration.php b/typo3/sysext/core/Configuration/DefaultConfiguration.php
index eedcc064355978e13b0652cc7d189421e1911914..037c6a4b8db135934b2238af28f1e649fd971e7e 100644
--- a/typo3/sysext/core/Configuration/DefaultConfiguration.php
+++ b/typo3/sysext/core/Configuration/DefaultConfiguration.php
@@ -1064,6 +1064,7 @@ return [
                 'email' => \TYPO3\CMS\Core\Database\SoftReferenceIndex::class,
                 'url' => \TYPO3\CMS\Core\Database\SoftReferenceIndex::class,
             ],
+            // cliKeys have been deprecated and will be removed in TYPO3 v9
             'cliKeys' => []
         ],
     ],
diff --git a/typo3/sysext/core/Documentation/Changelog/master/Deprecation-80468-CommandLineInterfaceCliKeysAndCli_dispatchphpsh.rst b/typo3/sysext/core/Documentation/Changelog/master/Deprecation-80468-CommandLineInterfaceCliKeysAndCli_dispatchphpsh.rst
new file mode 100644
index 0000000000000000000000000000000000000000..78452471edc47489dd45a9923e735467aff6f58e
--- /dev/null
+++ b/typo3/sysext/core/Documentation/Changelog/master/Deprecation-80468-CommandLineInterfaceCliKeysAndCli_dispatchphpsh.rst
@@ -0,0 +1,48 @@
+.. include:: ../../Includes.txt
+
+============================================================================
+Deprecation: #80468 - Command Line Interface: cliKeys and cli_dispatch.phpsh
+============================================================================
+
+See :issue:`80468`
+
+Description
+===========
+
+The functionality to register any command line script via php``$GLOBALS['TYPO3_CONF_VARS']['SC_OPTIONS']['GLOBAL']['cliKeys']['my_extension']`` has been marked as deprecated.
+
+The entrypoint ``typo3/cli_dispatch.phpsh`` as well as the corresponding Application class and
+the CliRequestHandler class have been marked as deprecated as well.
+
+The functionality has been superseded by Symfony Console and the new entry-point within
+``typo3/sysext/core/bin/typo3`` which is able to handle all functionality the same way including
+all Extbase-related Command Controllers.
+
+
+Impact
+======
+
+Calling the CLI entrypoint ``typo3/cli_dispatch.phpsh`` to call a CLI script will trigger a
+deprecation warning.
+
+
+Affected Installations
+======================
+
+Any installation using ``typo3/cli_dispatch.phpsh`` in any deployment or cronjob / scheduler
+functionality.
+
+
+Migration
+=========
+
+All functionality related to Extbase, EXT:lowlevel, or scheduler tasks can be called via
+the new entrypoint ``typo3/sysext/core/bin/typo3`` with a similar call.
+
+Update all cronjobs and automated and manual running scripts called via the command line to use
+the new entrypoint.
+
+If there any custom cliKeys registered, migrate them to a Symfony Command or an Extbase Command
+Controller.
+
+.. index:: CLI
\ No newline at end of file
diff --git a/typo3/sysext/extbase/ext_localconf.php b/typo3/sysext/extbase/ext_localconf.php
index 70b69a9fe43ea1761434d37e0d6efd1fa6aeb2b7..048fa541126c40c6f8466ac00936a51126a0d821 100644
--- a/typo3/sysext/extbase/ext_localconf.php
+++ b/typo3/sysext/extbase/ext_localconf.php
@@ -33,6 +33,7 @@ unset($extbaseObjectContainer);
 
 if (TYPO3_MODE === 'BE') {
     // registers Extbase at the cli_dispatcher with key "extbase".
+    // Using cliKeys is deprecated as of TYPO3 v8 and will be removed in TYPO3 v9, use Configuration/Commands.php instead
     $GLOBALS['TYPO3_CONF_VARS']['SC_OPTIONS']['GLOBAL']['cliKeys']['extbase'] = [
         function () {
             $bootstrap = \TYPO3\CMS\Core\Utility\GeneralUtility::makeInstance(\TYPO3\CMS\Extbase\Core\Bootstrap::class);
diff --git a/typo3/sysext/lowlevel/ext_localconf.php b/typo3/sysext/lowlevel/ext_localconf.php
index 8f892b0d8beb56f71c3e6148625b514486c7f81b..397b28084a36d14a5364e1627f54cf505c4d9541 100644
--- a/typo3/sysext/lowlevel/ext_localconf.php
+++ b/typo3/sysext/lowlevel/ext_localconf.php
@@ -3,6 +3,7 @@ defined('TYPO3_MODE') or die();
 
 if (TYPO3_MODE === 'BE') {
     // Setting up scripts that can be run from the cli_dispatch.phpsh script.
+    // Using cliKeys is deprecated as of TYPO3 v8 and will be removed in TYPO3 v9, use Configuration/Commands.php instead
     $GLOBALS['TYPO3_CONF_VARS']['SC_OPTIONS']['GLOBAL']['cliKeys']['lowlevel_cleaner'] = [
         function () {
             $cleanerObj = \TYPO3\CMS\Core\Utility\GeneralUtility::makeInstance(\TYPO3\CMS\Lowlevel\CleanerCommand::class);
diff --git a/typo3/sysext/scheduler/ext_localconf.php b/typo3/sysext/scheduler/ext_localconf.php
index 50614a053d489b441f1c2ecf56ea8b6783f5ac41..6f748032aaef3a6201b4b669a084b90489a11207 100644
--- a/typo3/sysext/scheduler/ext_localconf.php
+++ b/typo3/sysext/scheduler/ext_localconf.php
@@ -2,6 +2,7 @@
 defined('TYPO3_MODE') or die();
 
 // Register the Scheduler as a possible key for CLI calls
+// Using cliKeys is deprecated as of TYPO3 v8 and will be removed in TYPO3 v9, use Configuration/Commands.php instead
 $GLOBALS['TYPO3_CONF_VARS']['SC_OPTIONS']['GLOBAL']['cliKeys']['scheduler'] = [
     function ($input, $output) {
         $app = new \Symfony\Component\Console\Application('TYPO3 Scheduler', TYPO3_version);